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Naturally occurring carbohydrate that delivers a unique way to restore and sustain energy and also reduce muscle pain and stiffness.

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Product Description

Key Benefits

Per 0.25kg pack: 50 Serves
Per Serve: 5gm D Ribose
  Restore and sustain cellular energy
  Alleviate soreness or cramping
  Supports heart health
  Helps alleviate symptoms of myalgia
  Gluten free, Non-GMO
  Patented and clinically proven ingredient sourced from the USA

What is Ribose ?

D-Ribose (or simply ribose) occurs naturally in all living cells. It is a unique 5 carbon carbohydrate sugar that begins the metabolic process for ATP production- involved in the synthesis of adenosine triphosphate (ATP) in the muscle cell and works synergistically with Creatine.

Ribose has a slightly sweet taste and does not raise your blood sugar level.

In short, ribose is the essential component for your body’s basic production of energy. Without ribose, your cells cannot produce ATP, and without ATP you have no energy. Ribose has been proven to help increase muscular energy, boost stamina, and help recovery. D Ribose is also a very efficient way to improve your energy when working out. Ribose may be particularly useful for athletes who who exercise extensively and deplete energy reserves, and those involved in power sports such as sprinting and weight lifting.

Science behind Ribose:-

Ribose is the key structural backbone of critical cellular compounds called purines and pyrimidines. Our bodies must have an adequate supply of purines and pyrimidines in order to form major cellular constituents such as our genetic material (DNA and RNA), certain vitamins and numerous cofactors. In particular, ribose is the backbone of adenosine triphosphate (ATP) which is the source for all cellular energy. Ribose is the starting point and the rate limiting compound in the synthesis of these fundamental cellular compounds , thus the availability of ribose determines the rate at which they can be made by our cells and tissues

Ribose is unique in this metabolic role. No other compound can replace ribose in the important job of regulating the metabolic processes involved in synthesizing purines and pyrimidines. Without these vital structural components, our bodies would quickly run out of energy and be unable to make proteins. Furthermore, our cells would lose the ability to replicate. Energy recovery and tissue repair are slower in heart and muscle cells, especially after overwork or exercise. Ribose drives the process that replenishes ATP and other energy components in these cells.

Ribose is made in our bodies’ cells from glucose, but this process is slow in heart and muscle tissue. Although ribose is present in all living matter, only a small amount can be ingested through the diet. In many U.S. and European clinical studies, providing supplemental Ribose has been shown to significantly improve endurance during strenuous exercise, shorten recovery time, reduce cramping and soreness, and reduce fatigue in people suffering from energy depletion.

As with all LushProtein™ products, Certificates of Analysis (COA) are provided for all key ingredients for assured quality.


Nutritional Info

D Ribose per Serve [5000mg] %DV D Ribose(mg) 5000 * * % Daily Value (DV) not established    



D Ribose 

Ribose Reference List:

Here are studies studying the benefits of Ribose:

1. Andreoli S. Mechanisms of endothelial cell ATP depletion after oxidant injury. Pediatric Res
2. Angello D, R Wilson, D Gee, N Perlmutter. Recovery of myocardial function and thallium 201 redistribution
using ribose. Am J Card Imag 1989;3(4):256-265.
3. Asimakis G, J Zwischenberger, K Inners-McBride, L Sordahl, V Conti. Postischemic recovery of
mitochondrial adenine nucleotides in the heart. Circ 1992;85(6):2212-2220.
4. Baldwin D, E McFalls, D Jaimes, P Fashingbauer, T Nemzek, H Ward. Myocardial glucose metabolism and
ATP levels are decreased two days after global ischemia. J Surg Res 1996;63:35-38.
5. Befera N, A Rivard, D Gatlin, S Black, J Zhang, JE Foker. Ribose treatment helps preserve function of the
remote myocardium after myocardial infarction. J Surg Res 2007;137(2):156.
6. Brault JJ, RL Terjung. Purine salvage to adenine nucleotides in different skeletal muscle fiber types. J Appl
Physiol 2001;91:231-238.
7. Carter O, D MacCarter, S Mannebach, J Biskupiak, G Stoddard, EM Gilbert, MA Munger. D-Ribose improves
peak exercise capacity and ventilatory efficiency in heart failure patients. JACC 2005;45(3 Suppl A):185A.
8. Chatham J, R Challiss, G Radda, A Seymour. Studies of the protective effect of ribose in myocardial
ischaemia by using 31P-nuclear magnetic resonance spectroscopy. Biochem Soc Proc 1985;13:885-888.
9. Clay MA, P Stewart-Richardson, D Tasset, J Williams. Chronic alcoholic cardiomyopathy: Protection of the
isolated ischemic working heart by ribose. Biochem Internat 1988;17(5):791-800.
10. Cohen M, R Charney, R Hershman, V Fuster, R Gorlin, X Francis. Reversal of chronic ischemic myocardial
dysfunction after transluminal coronary angioplasty. JACC 1988;12(5):1193-1198.
11. Dodd SL, CA Johnson, K Fernholz, JA St.Cyr. The role of ribose in human skeletal muscle metabolism. Med
Hypoth 2004;62(5):819-824.
12. Dow J, S Nigdikar, J Bowditch. Adenine nucleotide synthesis de novo in mature rat cardiac myocytes.
Biochim Biophys Acta 1985;847(2):223-227.
13. Einzig S, JA St.Cyr, R Bianco, J Schneider, E Lorenz, J Foker. Myocardial ATP repletion with ribose infusion.
Pediatr Res 1985;19:127A.
14. Einzig S, J St. Cyr, J Schneider, R Bianco, J Foker. Maintained myocardial ATP with long-term ribose. Pediatr
Res 1986;20(4 pt 2):169A.
15. Gao W, Y Liu, E Marban. Selective effects of oxygen free radicals on excitation-contraction coupling in
ventricular muscle. Circ 1996;94:2597-2604.
16. Gebhart B, J Jorgenson. Benefit of ribose in a patient with fibromyalgia. Pharm 2004;24(11):1646-1648.
17. Geisbuhler T, T Schwager. Ribose-enhanced synthesis of UTP, CTP, and GTP from parent nucleosides in
cardiac myocytes. J Mol Cell Cardiol 1998;30(4):879-887.
18. Goncalves RP, GC Bennet, CP Leblond. Fate of 3
H-ribose in the rat as detected by autoradiography. Anat
Rec 1969;165:543-557.
19. Gradus-Pizlo I, SG Sawada, S Lewis, S Khouri, DS Segar, R Kovacs, H Feigenbaum. Effect of D-ribose on
the detection of the hibernating myocardium during the low dose dobutamine stress echocardiography. Circ

39. Lewandowski E, X Yu, K LaNoue, L White, C Doumen, M O’Donnell. Altered metabolic exchange between
subcellular compartments in intact postischemic rabbit hearts. Circ Res 1997;81:165-175.
40. Lortet S, HG Zimmer. Functional and metabolic effects of ribose in combination with prazosin, verapamil and
metroprolol in rats in vivo. Cardiovasc Res 1989;23:702-708.
41. Mahoney J, E Sako, K Seymour, C Marquardt, J Foker. A comparison of different carbohydrates as
substrates for the isolated working heart. J Surg Res 1989;47:530-534.
42. Mahoney J. Recovery of postischemic myocardial ATP levels and hexosemonophosphate shunt activity.
Med Hypoth 1990;31:21-23.
43. Mauser M, H Hoffmeister, C Nienaber, W Schaper. Influence of ribose, adenosine and “AICAR” on the rate of
myocardial adenosine triphosphate synthesis during reperfusion after coronary artery occlusion in the dog.
Circ Res 1985;56:220-230.
44. McDonagh TA, C Morrison, A Lawrence. Symptomatic and asymptomatic left-ventricular systolic dysfunction
in an urban population. Lancet 1997;35:829-833.
45. Muller C, H Zimmer, M Gross, U Gresser, I Brotsack, M Wehling, W Pliml. Effect of ribose on cardiac adenine
nucleotides in a donor model for heart transplantation. Eur J Med Res 1998;3:554-558.
46. Omran H, S Illien, D MacCarter, JA St. Cyr. Ribose improves myocardial function and quality of life in
congestive heart failure patients. J Mol Cell Cardiol 2001;33(6):A173.
47. Omran H, S Illien, D MacCarter, JA St. Cyr, B Luderitz. D-Ribose improves diastolic function and quality of life
in congestive heart failure patients: A prospective feasibility study. Eur J Heart Failure 2003;5:615-619.
48. Omran H, D MacCarter, JA St. Cyr, B Luderitz. D-Ribose aids congestive heart failure patients. Exp Clin
Cardiol 2004;9(2):117-118.
49. Pasque M, T Spray, G Peliom, P van Trigt, R Peyton, W Currie, A Wechsler. Ribose-enhanced myocardial
recovery following ischemia in the isolated working rat heart. J Thorac Cardiovasc Surg 1982;83(3):390-398.
50. Pasque M, A Wechsler. Metabolic intervention to affect myocardial recovery following ischemia. Ann Surg
51. Patton BM. Beneficial effect of D-ribose in patient with myoadenylate deaminase deficiency. Lancet 1982
52. Pauly D, C Pepine. D-Ribose as a supplement for cardiac energy metabolism. J Cardiovasc Pharmacol Ther
53. Pauly D, C Johnson, JA St. Cyr. The benefits of ribose in cardiovascular disease. Med Hypoth
54. Pauly DF, CJ Pepine. Ischemic heart disease: Metabolic approaches to management. Clin Cardiol
55. Perkowski D, S Wagner, A Marcus, J St. Cyr. Pre-surgical loading of oral d-ribose improves cardiac index in
pump coronary arterial revascularization. J Surg Res 2007;173(2):295.
57. Perkowski D, S Wagner, A Marcus, J St. Cyr. Ribose enhances ventricular function following off pump
coronary artery bypass surgery. J Alt Comp Med 2005;11(4):745

58. Perlmutter NS, RA Wilson, DA Angello, RT Palac, J Lin, BG Brown. Ribose facilitates thallium-201
redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
59. Pliml W, T von Arnim, A Stablein, H Hofmann, HG Zimmer, E Erdmann. Effects of ribose on exercise-induced
ischaemia in stable coronary artery disease. Lancet 1992;340:507-510.
60. Pliml W, T von Arnim, C Hammer. Effects of therapeutic ribose levels on human lymphocyte proliferation in
vitro. Clin Investig 1993;71(10):770-773.
61. Pouleur H. Diastolic dysfunction and myocardial energetics. Eur Heart J 1990;11(Supp C):30-34.
62. Redfield MM, SJ Jacobson, JC Burnett, DW Mahoney, KR Bailey, RJ Rodenheffer. Burden of systolic and
diastolic ventricular dysfunction in the community. Appreciating the scope of the heart failure epidemic. JAMA
63. Reibel D, M Rovetto. Myocardial ATP synthesis and mechanical function following oxygen deficiency. Am J
Physiol 1978;234(5):H620-H624.
64. Reimer K, M Hill, R Jennings. Prolonged depletion of ATP and of the adenine nucleotide pool due to delayed
resynthesis of adenine nucleotides following reversible myocardial ischemic injury in dogs. J Mol Cell Cardiol
Administration to a patient with inherited deficit of Adenylosuccinase. Adv Exp Med Biol 1998;431:177-180.
66. Salerno C, P D’Eufemia, R Finocchiaro, M Celli, A Spalice, C Crifo, O Giardini. Effect of D-ribose on purine
synthesis and neurological symptoms in a patient with adenylsuccinase deficiency. Biochim Biophys Acta
67. Sami H, N Bittar. The effect of ribose administration on contractile recovery following brief periods of
ischemia. Anesthesiol 1987;67(3A):A74.
68. Schneider J, J St. Cyr, J Mahoney, R Bianco, W Ring, J Foker. Recovery of ATP and return of function after
global ischemia. Circ 1985;72(4 pt 2):III-298.
69. Segal S, J Foley. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-735.
70. Seifert J, A Subudhi, M-X Fu, K Riska, J John. The effects of ribose ingestion on indices of free radical
production during hypoxic exercise. Free Rad Biol Med 2002;33(Suppl 1):S269.
71. Sharma R, M Munger, S Litwin, O Vardeny, D MacCarter, JA St. Cyr. D-Ribose improves Doppler TEI
myocardial performance index and maximal exercise capacity in stage C heart failure. J Mol Cell Cardiol
72. Siess M, U Delabar, H Seifart. Cardiac synthesis and degradation of pyridine nucleotides and the level of
energy-rich phosphates influenced by various precursors. Adv Myocardiol 1983;4:287-308.
73. Skadhauge-Jensen L, J Bangsbo, Y Hellsten. Availability of ribose is limiting for ATP resynthesis in human
skeletal after high-intensity training. Med Sci Sport Exc 2001;33(5)(Suppl1):S329.
74. Smolenski R, K Kalsi, M Zych, Z Kochan, M Yacoub. Adenine/ribose supply increases adenosine production
and protects ATP pool in adenosine kinase-inhibited cardiac cells. J Mol Cell Cardiol 1998;30(3):673-683.
75. Smolenski R, K Kalsi, M Zynch, Z Kochan, MH Yacoub. Effects of adenine/ribose supply on adenosine
production and ATP concentration in adenosine kinase inhibited cardiac cells. Adv Exp Med Biol
76. Smolenski R, J Jayakumar, AM Seymour, MH Yacoub. High-energy phosphate changes in the normal and
hypertrophied heart during cardioplegic arrest and ischemia. Adv Exp Med Biol 1998;431:283-6.

77. St. Cyr J, R Bianco, J Foker. Myocardial high-energy phosphate levels in cardiomyopathic turkeys. J Surg
Res 1986;41:256-259.
78. St. Cyr J, H Ward, J Kriett, D Alyono, S Einzig, R Bianco, R Anderson, J Foker. Long-term model for
evaluation of myocardial metabolic recovery following global ischemia. Adv Exp Med Biol 1986;194:401-441.
79. St. Cyr J, R Bianco, J Schneider, J Mahoney, K Tveter, S Einzig, J Foker. Enhanced high energy phosphate
recovery with ribose infusion after global myocardial ischemia in a canine model. J Surg Res
80. Swain JL, R Sabina, P McHale, J Greenfield, E Holmes. Prolonged myocardial nucleotide depletion after
brief ischemia in the open-chest dog. Am J Physiol 1982;242:H818-H826.
81. Taegtmeyer H, A Roberts, A Raine. Energy metabolism in reperfused heart muscle: Metabolic correlates to
return of function. JACC 1985;6(4):864-870.
82. Taegtmeyer H, L King, B Jones. Energy substrate metabolism, myocardial ischemia and targets for
pharmacotherapy. Am J Cardiol 1998;82(5A):54K-60K.
83. Taegtmeyer H. Metabolism ± The lost child of cardiology. J Am Coll Cardiol 2000;36(4):1386-1388.
84. Tan ZT. Ruthenium red, ribose and adenine enhance recovery of reperfused rat heart. Coronary Artery Dis
85. Teitelbaum JE, JA St.Cyr, C Johnson. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a
pilot study. J Altern Complement Med 2006;12(9):857-862.
86. Tullson PC, RL Terjung. Adenine nucleotide synthesis in exercising and endurance-trained skeletal muscle.
Am J Physiol 1991;261:C342-C347.
87. Tveter K, J St. Cyr, J Schneider, R Bianco, J Foker. Enhanced recovery of diastolic function after global
myocardial ischemia in the intact animal. Pediatr Res 1988;23:226A.
88. Vance R, S Einzig, K Kreisler, J St. Cyr. D-Ribose maintains ejection fraction following aortic valve
surgery. FASEB J 2000;14(4):A419.
89. Van Gammeren D, D Faulk, J Antonio. The effects of four weeks of ribose supplementation on body
composition and exercise performance in healthy, young male recreational bodybuilders: A double-blind,
placebo-controlled trial. Curr Ther Res 2002;63(8):486-495.
90. Vijay N, D MacCarter, M Washam, J St.Cyr. Ventilatory efficiency improves with d-ribose in congestive Heart
Failure patients. J Mol Cell Cardiol 2005;38(5):820.
91. Wagner DR, U Gresser, N Zollner. Effects of oral ribose on muscle metabolism during bicycle ergometer in
AMPD-deficient patients. Ann Nutr Metab 1991;35:297-302.
92. Wallen JW, MP Belanger, C Wittnich. Preischemic administration of ribose to delay the onset of irreversible
ischemic injury and improve function: studies in normal and hypertrophied hearts. Can J Physiol Pharmacol
93. Ward H, J St. Cyr, J Cogordan, D Alyono, R Bianco, J Kriett, J Foker. Recovery of adenine nucleotide levels
after global myocardial ischemia in dogs. Surgery 1984;96(2):248-255.
94. Williamson DL, PM Gallagher, MP Goddard, SW Trappe. Effects of ribose supplementation on adenine
nucleotide concentration in skeletal muscle following high-intensity exercise. Med Sci Sport Exc 2001;33(5
95. Wilson R, D MacCarter, J St. Cyr. D-Ribose enhances the identification of hibernating myocardium. Heart
Drug 2003:3:61-62.

96. Wyatt D, S Ely, R Lasley, R Walsh, R Mainwaring, R Berne, R Mentzer. Purine-enriched asanguineous
cardioplegia retards adenosine triphosphate degradation during ischemia and improves postischemic
ventricular function. J Thorac Cardiovsac Res 1989;97:771-778.
97. Zarzeczny R, JJ Brault, KA Abraham, CR Hancock, RL Terjung. Influence of ribose on adenine salvage after
intense muscle contractions. J Appl Physiol 2001;91:1775-1781.
98. Zimmer HG, E Gerlach. Stimulation of myocardial adenine nucleotide biosynthesis by pentoses and
pentitols. Pflugers Arch 1978;376:223-227.
99. Zimmer HG. Restitution of myocardial adenine nucleotides: Acceleration by administration of ribose. J
Physiol (Paris) 1980;76:769-775.
100. Zimmer HG, H Ibel, G Steinkopff. Studies on the hexose monophosphate shunt in the myocardium during
development of hypertrophy. Adv Myocardiol 1980;1:487-492.
101. Zimmer HG, H Ibel, G Steinkopff, G Korb. Reduction of the isoproterenol-induced alterations in cardiac
adenine nucleotides and morphology by ribose. Science 1980;207:319-321.
102. Zimmer HG. Normalization of depressed heart function in rats by ribose. Science 1983;220:81-82.
103. Zimmer HG, H Ibel. Effects of ribose on cardiac metabolism and function in isoproterenol-treated rats. Am J
Physiol 1983;245:H880-H886.
104. Zimmer HG, H Ibel. Ribose accelerates the repletion of the ATP pool during recovery from reversible
ischemia of the rat myocardium. J Mol Cell Cardiol 1984;16:863-866.
105. Zimmer HG, H Ibel, G Steinkopff. Ribose prevents the propranolol-induced reduction of myocardial adenine
nucleotide biosynthesis. Adv Exp Med Biol 1984;165(Pt B):477-481.
106. Zimmer HG, H Ibel, U Suchner. Ribose intervention in the cardiac pentose phosphate pathway is not
species-specific. Science 1984;223:712-714.
107. Zimmer HG, W Zierhut, G Marschner. Combination of ribose with calcium antagonist and beta-blocker
treatment in closed-chest rats. J Mol Cell Cardiol 1987;19:635-639.
108. Zimmer HG, PA Martius, G Marschner. Myocardial infarction in rats: Effects of metabolic and pharmacologic
interventions. Basic Res Cardiol 1989;84:332-343.
109. Zimmer HG. The oxidative pentose phosphate pathway in the heart: regulation, physiological significance
and clinical implications. Basic Res Cardiol 1992;87:3003-316.
110. Zimmer HG. Regulation of and intervention into the oxidative pentose phosphate pathway and adenine
nucleotide metabolism in the heart. Mol Cell Biochem 1996;160-161:101-109.
111. Zimmer HG. Significance of the 5-phosphoribosyl-1-pyrophosphate pool for cardiac purine and pyrimidine
nucleotide synthesis: studies with ribose, adenine, inosine, and orotic acid in rats. Cardiovasc Drug Ther
1998;12(Suppl 2):179-187.
112. Zollner N, S Reiter, M Gross, D Pongratz, CD Reimers, K Gerbitz, I Paetzke, T Deufel, G Hubner.
Myoadenylate deaminase deficiency: successful symptomatic therapy by high dose oral administration of
ribose. Klin Wochenschr 1986;64:1281-1290.

Suggested Use

Suggested Usage

 Add 1.5 tsp (5g) to water or juice, shake and consume immediately around 30 mins prior to exercise. Best on an empty stomach. 


Q.What is Ribose? A.D-Ribose (or simply ribose) is a simple, 5-carbon monosaccharide, or pentose sugar. It is used by all the cells of the body and is an essential compound in energy metabolism. Ribose also provides the structural backbone of our genetic material, DNA and RNA, certain vitamins and other important cellular compounds.

Q.How much Ribose should I take? A. For energy enhancement, 1.5 teaspoon (about 5 grams) is generally adequate. Ribose is mildly sweet and completely soluble. It mixes easily with your favourite juice, milk or other cold foods. To maximize athletic performance, or to keep energy pools high during strenuous activity, slightly larger doses may be of benefit. Bioenergy RIBOSE™ should be taken just before and just after exercise or activity. For extended exercise, an additional 1 – 2 grams per hour of exercise or activity may be helpful.

Q.When should I take Ribose? A. Ribose should be taken just before and just after exercise or activity. For extended exercise, an additional 1 – 2 grams per hour of exercise or activity may be helpful.

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